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Abstract

Background

A recent survey by the International Journal of Pharmacy shows that Cialis has been found to be the safest erectile dysfunction (ED) medication available. However, a high incidence of adverse events (AEs) and drug interactions have been reported in the community and are therefore not generally considered safe. This study aimed to investigate the safety of Cialis with respect to its use in the community and to evaluate the possible safety-related concerns and interactions with other medications.

Method

A cross-sectional study was carried out in the community and in the University Hospital of the Capital of China. A total of 15,366 patients (mean age: 49.8±11.5 years) with ED were randomly selected from the general population of the National Hospital of China (HNS) in Hubei Province (Hubei, China). The inclusion criteria were as follows: 1) the inclusion criteria included patients aged >18 years, with the diagnosis of erectile dysfunction and/or impotence; 2) the exclusion criteria included patients with erectile dysfunction requiring permanent prescription of Cialis, or with contraindications to any of the aforementioned medications, including nitrate drugs and/or phosphodiesterase inhibitors; 3) the exclusion criteria were patients with history of cardiovascular disease, diabetes, history of heart failure, uncontrolled hypertension, history of priapism, history of stroke, heart failure, heart attack, angina, uncontrolled hypertension, uncontrolled angina, severe liver impairment, active smokers, and active bleeding, or a history of heart failure; 4) the study exclusion criteria included patients with a history of cardiovascular disease, diabetes, hypertension, uncontrolled hypertension, history of priapism, history of stroke, heart failure, angina, uncontrolled hypertension, severe liver impairment, active smokers, active bleeding, and a history of heart failure; 5) the study excluded patients with chronic renal failure, patients with chronic liver disease, or those with a history of a severe adverse effect, and those patients who had recently experienced a sudden decrease in sexual ability in the previous 3 months; and 6) patients with a history of cardiovascular disease, diabetes, hypertension, uncontrolled hypertension, uncontrolled diabetes, or active smokers. The exclusion criteria were patients with a history of cardiovascular disease, diabetes, hypertension, uncontrolled diabetes, or active smokers.

A total of 16,366 patients (mean age: 48.1±11.5 years) with ED were randomly selected from the general population of the HNS in Hubei Province (Hubei, China). The inclusion criteria were as follows: 1) the exclusion criteria included patients with a history of erectile dysfunction and/or impotence; 2) the exclusion criteria included patients with a history of impotence requiring permanent prescription of Cialis, or with contraindications to any of the aforementioned medications, including nitrate drugs and/or phosphodiesterase inhibitors; 3) the exclusion criteria were patients with a history of cardiovascular disease, diabetes, hypertension, uncontrolled hypertension, uncontrolled diabetes, and active smokers. We excluded patients who have a history of heart failure, a history of heart failure, angina, uncontrolled hypertension, uncontrolled diabetes, and active smokers.

Results

A total of 15,366 patients (mean age: 49.8±11.5 years) were enrolled in the study. The exclusion criteria were as follows: 1) patients with a history of cardiovascular disease, diabetes, hypertension, uncontrolled hypertension, uncontrolled diabetes, and active smokers; 2) patients with a history of heart failure, angina, uncontrolled hypertension, uncontrolled diabetes, and active smokers; 3) patients with a history of heart failure, angina, uncontrolled hypertension, uncontrolled diabetes, and active smokers; 4) patients with a history of cardiovascular disease, diabetes, hypertension, uncontrolled hypertension, uncontrolled diabetes, and active smokers; 5) patients with a history of heart failure, angina, uncontrolled hypertension, uncontrolled diabetes, and active smokers; and 6) patients with a history of heart failure, angina, uncontrolled hypertension, uncontrolled diabetes, and active smokers. The majority of the patients in the study had a past history of cardiovascular disease, diabetes, hypertension, uncontrolled hypertension, uncontrolled diabetes, and active smokers. The majority of the patients in the study had a history of heart failure, angina, uncontrolled hypertension, uncontrolled diabetes, and active smokers. A total of 15,366 patients (mean age: 48.1±11.5 years) were enrolled in the study.

Cialis Super Active 20mg

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Generic name: Cialisoxadrenergic receptor agonistotherwise known as TadalafilandPDE5 inhibitor

Pronunciationtadalafilorpde5 inhibitor

Brand name: Cialisotherwise known as

About Cialis

Cialis is a prescription medication primarily used to treat erectile dysfunction (ED) and symptoms of benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the penis, thereby increasing blood flow into the penis on sexual stimulation. Cialis is most effective when combined with sexual stimulation.

Cialis is not a cure for ED or a first-line treatment. It works by increasing blood flow to the penis, facilitating an erection. However, it does not guarantee that an erection will occur within 6 hours.

While Cialis is highly effective, it may take several months to achieve a full response. Once an erection occurs, the medication is not recommended for continued use.

If your symptoms persist or if you have sudden vision loss, contact your healthcare provider.

Uses of Cialis Super Active 20mg

Cialis Super Active 20mg is used to treat:

Erectile dysfunction: This medication is used to treat erectile dysfunction in men by increasing blood flow to the penis during sexual stimulation.

Benign prostatic hyperplasia (BPH): This medication is used to treat BPH by relaxing the muscles in the prostate and bladder.

How to use Cialis Super Active 20mg

Cialis Super Active 20mg should be taken as directed by your doctor, usually as needed, about 30 minutes to 1 hour before sexual activity. Swallow the tablet whole with a full glass of water. Do not crush or chew the tablet. Cialis Super Active 20mg can be taken with or without food, but it is recommended to take it at the same time each day.

Dosage

The dosage of Cialis Super Active 20mg depends on the severity of the condition being treated, the age, and the response to treatment.

The typical starting dose for benign prostatic hyperplasia is 10 mg once-daily. However, it is important to continue taking the medication as prescribed even if your symptoms improve. Cialis Super Active 20mg should be taken at least one hour before engaging in sexual activity. The maximum recommended dosing frequency is once per day.

It is not advisable to split or chew the medication since the drug will not work uniformly.

Side effects of Cialis Super Active 20mg

Some people may experience side effects while taking Cialis Super Active 20mg. These side effects include:

  • Flushing (redness and warmth in the face, ears, neck, and trunk)
  • Indigestion or upset stomach
  • Nasal congestion
  • Muscle pain or weakness
  • Rash
  • Headache

If any side effects persist or if you experience any serious side effects, contact your doctor immediately. A full list of side effects is provided in the manufacturer's.

If you are using this medication to treat erectile dysfunction and chest pain, read the manufacturer's printed information leaflet included with your order. If you are not sure, contact your doctor or pharmacist for help. Cialis Super Active 20mg may rarely cause sudden vision loss, which may require urgent medical attention.

If you experience signs of an allergic reaction to Cialis Super Active 20mg, such as rash, itching, swelling, dizziness, or difficulty breathing, seek immediate medical help. Stop taking Cialis Super Active 20mg and get immediate medical help right away if you notice these signs.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

If you are taking Cialis or related medications, it is important for your healthcare provider to have a discussion with you regarding the appropriate use of these medications.idepressant. offers “on-demand” consultations with licensed doctors, allowing you to receive care promptly andIronicallyAppImplateAlgia(pp) - Inc. - Inc.Other Drug-Food interactions:When using other drugs with Cialis, please be aware that the following drugs may interact with Cialis:

C.

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